Path of Exile is a much better game
I switched back to Path of Exile from Diablo III after growing tired of the game never changing, the game had changed quite a bit but Path of Exile is a much better game now I'd say.
1.) This is down to you entirely, builds in Diablo III are very easy to modify whenever you wish but this is not the case in PoE. You spend points on the skill tree and whilst you do get some re-spec points that allow you to change things, making large changes to a build will require the use of a currency known as an 'Path of Exile Orb of Regret' to give you more re-spec points.
Without trying to overload you with info I would suggest you take a read through the active skill gems on the wiki, see what sounds interesting to you and make a build selection based around that. If more than one sounds interesting then pick an archetype (e.g. melee, caster, summoner etc) and fiddle with skills til you find out what you like.
Unlike Diablo III, you aren't restricted in skill selection based on items giving bonuses to ability X but not ability Y. So in Diablo there would be no real reason to use say the DH skill Multishot if you're playing the Natalya's Set because there are better sets for that skill. In Path of Exile you can make most things 'work' but it depends what you're trying to achieve.
2.) This is a bit of a sore point for some of the community but Path of Exile is a bit closer to vanilla Diablo III here, you go through the story 2.5/3 times and then get to endgame.
3.) This will depend on what general ARPG knowledge you already have but I'll highlight some important stuff: the economy is based around a variety of different poe orbs that all have their own value against other currency - think how the US$ will have a given value against the Euro but will have a different value against say Japanese Yen. Trading is largely unrestricted unlike Diablo III so if you get a good drop then you can safely store it away and know that you can give it to a friend or sell it later. Defensive mechanics are a bit more complex than Diablo III in that there are essentially two different health bars you could potentially have: Life and Energy Shield - I won't go into detail about them but generally you stack up on one or the other, life is easier to understand and closer to it's function in Diablo III so I'd start with that (so ignore builds that mention 'CI' or 'ES').

Aug
poe4orbs:[Lake Of Kalandra] PoE 3.19 Templar Starter Builds
Here is the latest PoE 3.19 Templar League Starter | Fast | Endgame | Cheap Builds brought to you by PoECurrencyBuy.

Nov
Make skin microtransactions easier to retrieve in Path of Exile
instead of the current look through all your tabs and characters until you find that one skin you are looking for method, my proposal is to have non-consumable skins permanently displayed on your microtransactions stash

Jan
Cheap Path of Exile Currency Sale Opens at Poe4orbs.com
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Oct
Low-cost, fast and Safe - Poe4orbs offers the best Path of Exile ORBS
Poe4orbs low-cost, fast and safe Path of Exile ORBS is getting much popularity, thousands of people have bought millions of POE ORBS

May
Path of Exile Level And Gear Guide
We all know that there are a lot of maps in Path of Exile, which can be used to level and gear. But you still need a detailed guide on how to do these step by step, so I am going to show you.

Aug
poe4orbs:[Lake Of Kalandra] PoE 3.19 Witch Starter Builds
Here is the latest PoE 3.19 Witch League Starter | Fast | Endgame | Cheap Builds brought to you by PoECurrencyBuy.